The Orengo group is probably best known for creating and maintaining the CATH resource (classification of protein structural domains), however the group is also involved in many other research areas.

Protein Structure

  • Identification of structural protein domains (CATH)
  • Classification of structural domains into evolutionary superfamilies (CATH, Protein Chart)
  • Analysis of evolutionary relationships (CATH)
  • Structure comparison (SSAP, CATHEDRAL)

Protein Sequence

  • Mapping genomic sequences onto structural superfamilies (Gene3D)

Protein Function

  • Assignment of functional terms (FLORA, FunFam)


  • Development of protocols and standards to assist communication between bioinformatics resources (EMBRACE)

Alternative Splicing

  • Studying ┬áthe functions of alternative splicing in development